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DTP Enablement

A Comprehensive Guide to Direct-To-Patient (DTP) Enablement for Pharma

A Comprehensive Guide to Direct-To-Patient (DTP) Enablement for Pharma

A Comprehensive Guide to Direct-To-Patient (DTP) Enablement for Pharma

Pharmaceutical professional reviewing digital tools in a clinical workspace

Table of Contents

The traditional model, where pharmaceutical companies reached patients only through clinicians, specialty pharmacies, and clinical sites, is rapidly giving way to a more direct approach. As patient expectations evolve and regulations adapt, leading manufacturers are expanding into direct-to-patient (DTP) models by launching digital storefronts, offering cash-pay pathways, and integrating telehealth, affordability services, and home delivery in unified experiences. 

In the last 2 years, companies like Eli Lilly (launching LillyDirect), Pfizer, Novo Nordisk (launching NovoCare), AstraZeneca, and others launched prominent DTP platforms to connect directly with patients. But the future of pharma’s DTP evolution is not simply about setting up online pharmacies or shipping pills to doorsteps. This shift is transforming how therapies are delivered, how patients are supported, and how data-driven insights are generated. 

Whether you’re evaluating your first DTP pilot or scaling an existing program, this guide provides an evidence-based overview of what DTP enablement is, why it matters now, and how to operationalize it in a commercial context. We’ll break down core components of successful DTP models, examine their impact on pharmaceutical commercialization (from patient access to brand loyalty), discuss common implementation challenges, and highlight best practices drawn from real-world deployments. 

By the end, you’ll have a solid understanding of how DTP ecosystems work and a practical framework for integrating them into your organization’s strategy.

Key Takeaways

  • Strategic Imperative: DTP enablement has evolved from niche experiments to a mainstream strategy. A recent industry survey found 94% of pharma companies are either running, planning, or exploring DTP programs within the next year, showing that direct-to-patient is becoming standard practice across the sector.

  • Commercial Impact: Well-designed DTP models can significantly boost a brand’s performance. They typically deliver a 4:1 to 6:1 ROI within a few years and can capture 15-25% of total prescription volume by bypassing common access barriers. By accelerating time-to-therapy and improving retention, DTP programs create both better health outcomes and substantial financial returns.

  • Patient-Centric Focus: The top driver for adopting DTP is improving patient experience and meeting patients’ expectations for convenience. Successful DTP programs prioritize a seamless, supportive journey, from easy online consultations to transparent pricing and home delivery, while keeping healthcare providers involved for clinical oversight. In fact, over 75% of physicians say they would recommend pharma-run patient portals to help patients with medications, indicating that direct-to-patient models can complement, not replace, in-person physician care.

What Is DTP Enablement?

Direct-to-Patient (DTP) describes pharma’s ability to interact directly with patients to support access and treatment, with services such as affordability support, telehealth, and delivery when appropriate. In practice, a DTP program creates a complete operational pathway owned (or orchestrated) by the manufacturer, which usually includes:

  • Prescription intake via local or telemedicine providers: Patients can obtain a prescription from their existing local healthcare provider or through a licensed telemedicine consultation, depending on preference and state rules.

  • Coverage, benefits, and affordability workflows: Real-time insurance verification, prior authorization support, co-pay assistance, and cash-pay options that reduce payer friction and ensure patients can start therapy quickly.

  • Patient-facing portal: A website or app where patients register, order medication, schedule delivery, access educational resources, and receive support.

  • Patient support and follow-up: Pharmacists or support staff are available (via chat, phone, or telemedicine) for counseling, adherence monitoring, refills, and addressing questions or side effects.

  • Medication fulfillment and delivery (when included): Prescriptions can be routed to a partner pharmacy for dispensing, with optional home delivery depending on the therapy and program design.

DTP enablement is not defined solely by home delivery; it is a comprehensive framework of technology, coverage workflows, compliance, and patient services that enables pharma companies to coordinate the full patient journey directly with patients.

Why DTP Matters Now

Several factors have made direct-to-patient enablement one of pharma’s top strategic priorities in recent years.

Expanding Access for Underinsured and Cost-Burdened Patients

Even when patients are willing to begin therapy, cost and administrative friction can prevent them from accessing the treatment they need.

DTP programs help close this gap by creating an additional, more accessible pathway for patients who cannot secure coverage or timely authorization. For example, a DTP model may pair an online consultation with transparent cash-pay pricing, manufacturer-sponsored affordability programs, or co-pay support, making therapy attainable for patients who would otherwise drop off.

For many brands, this is the number-one reason to invest in DTP enablement: ensuring that motivated patients can start and stay on therapy regardless of insurance hurdles.

Policy & Pricing Changes

Industry economics are being reshaped by policies like the Inflation Reduction Act in the U.S., which imposes pricing changes that squeeze traditional rebate-driven models. Rebate reforms and “Most-Favored-Nation” pricing rules are pushing pharma to rethink the status quo, and DTP offers a more sustainable, direct revenue pathway in certain cases. 

By facilitating direct access to the patient (often at a steep discount and without middleman markups), manufacturers can retain more control over pricing strategies and margins over the long term.

Consumer Expectations

Patients, especially younger generations, have been conditioned by technology, and specifically e-commerce, to expect convenience, transparency, and speed in all transactions. Healthcare is no exception. 

Millennials and Gen Z now represent over half the population, and “for younger demographics, seeking medication online should feel as natural as any other purchase”. In a recent survey, 81% of patients expect pharma companies to provide resources to help them manage their care, and 65% believe pharma should offer digital tools and support services as part of the treatment experience. 

Three-quarters of U.S. consumers say they’d consider purchasing medications directly from a pharma company if it provided a simpler, more transparent experience. 

Pharma companies that meet these expectations can differentiate themselves and build patient loyalty, while those that don’t risk losing relevance in an increasingly “consumerized” healthcare landscape.

Therapy Fit & New Categories

Certain types of therapies are especially well-suited to direct-to-patient channels. These tend to be “specialty-lite” or lifestyle medications that patients are already seeking out proactively. For example, treatments in dermatology, weight management (e.g., GLP-1 medications), migraine, fertility, or other self-managed chronic conditions. Such products often have high consumer awareness and don’t require intensive in-person monitoring, making them ideal for a mostly digital delivery model. 

Similarly, therapies that are self-administered (oral pills, autoinjectors, etc.) are prime candidates for DTP because patients can take them at home without a clinician. We also see DTP being attractive for brands in highly competitive classes (where ease of access could sway a patient’s choice and build stickiness) and “access-challenged” brands (medications with restricted coverage or approaching loss of exclusivity). 

In those cases, a DTP channel can provide a critical safety net to keep patients on therapy and maintain brand loyalty even as payer support decreases or generic competition increases.

Pharma Companies Are Heavily Investing in DTP Enablement

According to a 2025 industry survey, 94% of pharma leaders say they either have a DTP program running, plan to launch one in the next year, or are actively exploring the option. The entire industry is now leaning into DTP, in some form. Over half of those surveyed even predict that DTP will become standard practice for most brands within five years.

This wave of adoption is driven by tangible business benefits and competitive pressures, not just hype. Early adopters have reported that DTP programs can boost patient acquisition and retention in ways that translate to topline growth. Aaron Uydess of EVERSANA noted that well-designed DTP models typically yield about a 4:1 to 6:1 return on investment (ROI) after three years.

Much of this value comes from capturing scripts that otherwise would be lost. Uydess estimates a strong DTP program can capture between 15% to 25% of total script volume for a brand by removing access hurdles and reaching patients who might not have gone through the usual pharmacy route. For a blockbuster drug, this can equate to hundreds of millions in revenue retained or gained. It comes as no surprise that even historically conservative pharma companies are investing in DTP pilots and expansions.

Real-world examples illustrate the commercial impact. In cardiovascular care, Amgen’s DTP initiative for Repatha, a cholesterol-lowering injection, offered 60% discounts and streamlined access, resulting in the “lowest U.S. net price among G7 countries” and attracting cost-sensitive patients who might otherwise abandon therapy. 

Bristol Myers Squibb launched a cash-pay DTP portal for its psoriasis drug, Sotyktu, with an 80% discount, vastly lowering the barrier for patients facing insurance denials. AstraZeneca, Novartis, and Boehringer Ingelheim have similarly rolled out direct channels with steep price reductions for certain medications. These programs are not just promotional. They are capturing patients who were slipping through the cracks, translating into higher initiation and retention rates for the brands.

Key Components of Successful DTP Enablement

Implementing DTP capabilities is a complex task that covers multiple domains. Based on industry deployments and survey feedback, several core components (or pillars) are essential for a successful DTP program.

Technology Infrastructure & Digital Experience

At the heart of DTP is a robust digital platform that ties everything together. Patients should have a single, user-friendly interface that serves as the program's “digital front door.” Through this portal, they can learn about the therapy, consult a provider if needed, enroll in support programs, arrange delivery, and get follow-up care, among other things. 

Leading pharma companies have learned that integrating these functions into a single, seamless system is better than stitching together multiple siloed vendors. In early DTP efforts, it was common to use one vendor for telehealth, another for pharmacy, and another for nursing support, which often required patients to switch between websites or repeat their information. 

This fragmentation creates frustration and drop-off. “Patients face a multi-vendor obstacle course requiring the same information entered multiple times” resembling a high-friction DIY project rather than streamlined commerce. 

Here’s a list of the crucial capabilities that the tech infrastructure should include:

  • Telehealth integration: so that patients can get a prescription from a licensed clinician online if they don’t already have one. This often means embedding or partnering with telemedicine services within the DTP portal.

  • E-prescribing and pharmacy system integration: to route prescriptions directly to the dispensing pharmacy and provide patients with status updates.

  • Benefits verification and coverage assessment: Used to instantly check insurance coverage and benefits, determine patient eligibility, and streamline prior authorization or copay support enrollment. Insurance should not be bypassed entirely, as this can lead to higher overall expenses for some patients due to failure to meet deductibles or out-of-pocket limits.

  • Payment and affordability options: Tools that process credit card payments for cash-pay transactions and apply manufacturer-sponsored co-pay assistance, discounts, or other affordability programs.

  • Patient communication tools: such as a live chat, chatbots, or phone support, integrated into the platform. Many patients have questions about their medication or the process. Features such as live chat for answers (44% of patients want this) or AI-driven chatbots for quick FAQs can greatly enhance the experience.

  • Automated notifications: so patients can receive updates about order status, shipment tracking, and refill reminders.

  • Data analytics and CRM: available on the backend, through which the platform can capture all user interactions and feed a data warehouse or CRM system. This allows the pharma company to monitor program performance in real time (e.g., funnel conversion rates, adherence rates) and to trigger interventions.

To demonstrate the importance of an integrated approach, consider e-commerce. Every extra click or form field can reduce the conversion rate. The same applies to DTP. Pharma companies report that consolidating vendors and creating an all-in-one experience directly improves patient uptake and satisfaction.

Logistics & Supply Chain Management

Behind the digital front end lies the heavy lifting of logistics: getting a regulated, often sensitive medical product from Point A (manufacturer or pharmacy) to Point B (patient) efficiently and safely.

There are a couple of models for DTP fulfillment:

  • Some programs use a centralized mail-order pharmacy or depot that ships directly to patients (often a national partner pharmacy licensed across all required states)

  • Others may route through local sites or pharmacies (decentralized) if specific handling is needed

Regardless of model, key logistics capabilities include:

  • Secure, timely shipping: medications, especially specialty drugs like injectables, biologics, or gene therapies, may require cold-chain packaging, temperature monitoring, and rapid delivery to maintain efficacy. A break in the cold chain or a delayed delivery could ruin the product and harm the patient.

  • Tracking and notifications: Both the patient and the pharma company should be able to track shipments in real time. Patients appreciate knowing exactly when their medication will arrive (think of how consumer e-commerce gives you package tracking to your doorstep).

  • Inventory and supply management: Offering DTP means the manufacturer (or its logistics partners) must manage inventory availability for direct orders. If a patient is ready to order but the product is on backorder or stuck in distribution channels, it undermines trust.

  • Regulatory compliance in distribution: Ensuring shipments comply with all regulations (e.g., DSCSA track-and-trace serialization, which in the U.S. mandates that individual prescription drug packages be traceable, or handling of controlled substances per DEA rules if applicable). A DTP program needs processes to verify that the right patient receives the right drug with appropriate documentation.

Neglecting the logistics component can be a fatal flaw for DTP initiatives. A patient’s experience is not just about website usability; it also depends on whether the medication arrives on time and in good condition.

Regulatory Compliance & Legal Considerations

A 2023 industry survey found that 45% of pharma companies identified “compliance and legal concerns” as the primary barrier to launching DTP programs.

In the United States, pharmacy practice is regulated at the state level, meaning what’s permissible in one state (for mailing prescriptions, telehealth prescribing, etc.) might be restricted in another.

Key compliance areas to address include:

  • Pharmacy and dispensing laws: If the DTP model involves direct dispensing, the entity shipping the drug typically must be a licensed pharmacy or distributor. Many manufacturers address this by partnering with an existing mail-order pharmacy network or contracting with a licensed specialty pharmacy to fulfill DTP orders on their behalf.

  • Telehealth and prescribing regulations: Because DTP often uses telemedicine to generate prescriptions, compliance with telehealth laws is critical. This includes complying with the Ryan Haight Act when prescribing controlled substances and adhering to any state-specific telemedicine rules (e.g., requiring a video consultation rather than a phone call).

  • Advertising and promotion rules: When engaging directly with patients, manufacturers must ensure their communications comply with FDA and other regulatory guidelines governing promotion. For example, if the DTP portal includes medication information or promotional content, it must balance benefit claims with appropriate risk disclosures.

  • Quality and pharmacovigilance: Delivering drugs directly means the manufacturer may also need to consider how to handle adverse event reporting and product quality issues reported by patients. In the traditional model, these might be filtered back through healthcare providers or pharmacies. In a DTP model, if a patient reports a side effect during a support call, the company’s pharmacovigilance processes must capture and report it in accordance with FDA requirements.

Many companies form cross-functional working groups (including regulatory affairs, legal, quality assurance, and compliance officers) to map out the requirements for each region and ensure the program is built to meet them. In some cases, organizations even proactively seek FDA feedback or state board of pharmacy input.

Patient Engagement & Support Services

While technology and logistics are crucial, patient engagement is the glue that makes DTP truly patient-centric. The best DTP programs actively support patients at each step to maximize success in therapy. This is where human touch and thoughtful service design come in.

Here are some of the most important elements of patient support in DTP programs.

Onboarding and education

When a patient first enters the program, the process should onboard them smoothly by collecting their information, obtaining informed consent where needed, and documenting their medical history for the prescriber. This should be as frictionless as possible (e.g., auto-fill forms, insurance card photo uploads), as complex forms can deter people. 

Once they’re in, providing clear education about the medication is key. This might be via an online learning module, nurse call, or multimedia content. Patients need to know how to take their medication properly, what to expect, and how the DTP service will support them. 

Some DTP programs even mail a welcome kit with printed instructions and contact info for help.

24/7 Access to Help

Questions or issues can arise at any time (e.g., an injection was more painful than expected or a delivery is late). Leading programs offer around-the-clock access to someone who can help, whether it’s a pharmacist on call, a nurse hotline, or at least a chatbot that can escalate to a live person. 

Even if 24/7 live support isn’t feasible, extended-hours coverage is important because patients may be using the medication outside business hours.

Adherence monitoring

One of the benefits of DTP is improved adherence, driven by active monitoring and intervention. Many DTP programs incorporate proactive outreach. 

For example, if a patient is due for a refill but hasn’t ordered by a certain date, the system can trigger a reminder notification or a call from a support specialist to ask whether they need help refilling. 

Some programs integrate smart devices or apps that remind patients to take doses or track symptoms. In cases of complex therapies (such as an injectable for rheumatoid arthritis), a nurse might schedule periodic virtual check-ins to monitor the patient's progress. 

Feedback loops and patient-reported outcomes

Effective DTP models treat patients as partners and sources of insight. This can involve prompting patients to report how they’re feeling, any side effects, or their disease progress.

Simple surveys or in-app check-ins can, with consent, gather valuable data on how the patient is responding to therapy. For example, if many patients report fatigue at week 2 of a therapy, the program can proactively send information about managing that side effect or alert physicians.

Not only does this demonstrate that the company cares about the patient’s health, which is one of the main reasons companies implement DTP, but it can also feed into a better understanding of the medication’s real-world effectiveness and inform support needs. 

Common DTP Program Challenges and How to Overcome Them

Despite the promising benefits, implementing a DTP program presents challenges.

Maintaining Provider Relationships

A concern some stakeholders raise is whether DTP models alienate healthcare providers (HCPs), such as physicians and local pharmacies. Doctors might worry that pharma is trying to “go around” them to get to patients, and pharmacists might fear being cut out. 

In reality, for prescription drugs, physicians remain central. No one gets a prescription without a licensed provider’s approval in a legitimate DTP program. The intention is not to replace a patient’s current doctors, but to supplement their care by reducing administrative burden and providing greater convenience for patients. 

Many programs actually rely on physicians to refer appropriate patients. For example, a dermatologist could tell a patient, “You can get this medication through the manufacturer’s direct program for fast home delivery and support,” which might improve the patient’s likelihood of starting treatment. 

The data suggests HCPs are open to this. In one survey, 77% of healthcare providers said they would recommend DTP services or portals to patients for medication info and support. 

Many DTP programs still have physicians conducting telehealth consults and pharmacists dispensing medications, so it’s more about reconfiguring service delivery than about removing healthcare professionals.

Internal Organizational Silos

Implementing a DTP program requires coordination among the following departments: commercial (marketing and sales), medical affairs, supply chain, IT, legal, and patient support services. 

This can impede DTP efforts, which demand a “one team” approach. For example, the commercial team might sponsor it for marketing reasons, but it won’t succeed without the supply chain team ensuring distribution and IT building the platform. One survey of pharma executives found that over 60% cited internal silos as a major barrier to patient-centric initiatives like DTP.

Many companies establish a cross-functional steering committee or task force for DTP implementation, led by a high-ranking champion (e.g., a Chief Digital Officer or Head of Commercial Innovation). 

This group should set shared objectives that transcend individual brands. For instance, field sales teams or brand managers worry that DTP will cannibalize their numbers, so they are reassured by counting DTP-originated prescriptions toward their goals or by framing DTP as bringing in new patients rather than shifting existing ones. 

Budget and ROI Clarity

While we noted earlier that the long-term ROI is promising, in the short term, DTP programs require significant investment in technology, new hires, vendor contracts, and patient subsidies (e.g., free shipping, discounts). 

It can be challenging to get budget approval without clarity on how to measure success. Is DTP a marketing expense, a distribution cost, or a patient support program? Who owns the P&L for it? Overcoming this involves building a strong business case and transparent metrics. 

Leverage early data (from pilots or industry benchmarks) to project the impact on prescription volume and adherence. Also, start with a pilot if needed to gather internal data. For example, run DTP for one brand in one region, measure the outcomes for 6-12 months, then expand. Demonstrating even a few percentage-point increases in conversion or retention can translate into significant revenue gains, which helps justify additional budget.

Often, the combination of improved patient outcomes and strong business outcomes will satisfy both commercial and medical/compliance stakeholders, demonstrating that the program is worth it.

Best Practices for Implementing DTP Programs

Drawing on lessons from industry professionals, surveys, and expert analyses, here are several best practices to guide the planning and rolling out of DTP initiatives.

1. Start with a Strategic Assessment, Since Not Every Drug Needs DTP

Before building a DTP platform, take a step back and evaluate which products or patient populations are most suitable for a direct model. DTP is not a one-size-fits-all solution. Some therapies are better suited than others. 

Key factors to assess include:

  • Clinical suitability: Can the medication be used safely at home without direct medical supervision? Oral drugs, self-injectables, or devices that patients can manage are good candidates. If a drug requires in-clinic administration or extensive monitoring (e.g., certain infused biologics), a pure DTP approach may not be feasible; however, hybrid models (e.g., home nursing visits) could be considered.

  • Patient demand and digital readiness: Is the target patient population likely to embrace a digital home-delivery option? For example, younger patients or those with mobility issues might strongly prefer it. If the therapy addresses a stigma-laden condition (e.g., hair loss, sexual health) where discretion is valued, DTP could be very attractive. However, elderly patients or those in acute care might not engage as readily online (though caregivers could).

  • Market access and business rationale: Define the problem you aim to solve with DTP. Is it to increase access in a category where patients can’t get the drug easily (due to insurance barriers or lack of nearby specialists)? Or to differentiate in a crowded market by offering superior service? Or to extend the product’s life as it goes off patent by building direct patient relationships? For instance, if you have a drug with limited insurance coverage, a DTP cash-pay option could capture patients who would otherwise drop off. If you have a new drug in a competitive class, DTP could be a way to gain market share via convenience.

  • Operational feasibility: Can you reliably deliver this therapy to patients? If a drug requires a sub-zero cold chain (e.g., certain cell/gene therapies or vaccines), do you have the infrastructure or partners to manage it? If a therapy has complex reimbursement (like coverage under medical vs. pharmacy benefits), can your system integrate those checks? It might be wise to start with a simpler use case for piloting: for example, select a self-pay dermatology cream rather than an oncology infusion as the first DTP test.

By performing this initial assessment, you can prioritize which DTP initiatives will deliver the most value with the least resistance. Many companies start with one or two brands that meet favorable criteria (self-administered, high unmet need, etc.), prove the model there, and then generalize the approach more broadly.

2. Design an Integrated, End-to-End Patient Journey

Integration is the core of DTP success. As shown earlier, a common pitfall is a fragmented approach that stitches together multiple vendors and touchpoints, leading to a disjointed patient experience. 

The best practice is to map out the entire patient journey, from first awareness or referral all the way to refill, and build an integrated workflow for each step. This way, the patient feels they are dealing with a single entity and have a clear understanding of their case throughout the process, rather than being passed along a chain.

To achieve this integration:

  • Conduct journey mapping workshops with all stakeholders. Plot what a patient should ideally experience at each stage, perhaps using patient personas. Identify potential pain points or drop-off points and address them in the design. For instance, if the journey map shows a gap between prescription and delivery where a patient might wonder, “Was my order approved?”, include a status update notification there.

  • Consolidate vendors where possible. If you have existing partnerships, explore if one of them can expand services to cover more pieces, or if a new platform could replace both. Fewer hand-offs mean fewer integration headaches. However, ensure any “all-in-one” partner is truly capable across all areas, as niche expertise may still be needed (e.g., a telehealth partner with licensed prescribers in all 50 states or a pharmacy network with the right accreditations).

  • Plan for data flow and integration behind the scenes. All entities involved (the telehealth provider, the pharmacy, the support team, etc.) should share data in near-real-time to keep the journey cohesive. For example, the moment a doctor writes an electronic prescription, the pharmacy should get it, the patient portal should update (“Prescription approved!”), and the benefit verification should kick off. That requires the systems to talk to each other. 

If the first cohort of patients finds it easy and helpful, word will spread, and more will enroll. Some companies even quietly beta-test with friendly patients or employees to iron out kinks.

3. Engage Regulators and Compliance Teams Early

Early engagement with regulatory bodies and internal compliance is essential to help avoid pitfalls down the road.

Here is a list of tips we recommend following:

  • Involve your compliance/legal team from the start of the project. Make them part of the core planning group. It’s better to have them voice concerns and help craft solutions in the design phase than to have them veto something right before launch. For example, legal might advise on wording for patient consents, or compliance might highlight that a certain state prohibits manufacturer coupons for Medicare patients, which you can then account for in the DTP program logic.

  • Address state-level variability upfront. Creating a matrix of states vs. key program elements (telehealth, pharmacy shipping, nursing support, etc.) to spot any problematic states can be very useful. Some companies do a phased rollout, launching in the majority of states first and adding the more challenging ones later as they resolve issues (e.g., states that require in-state physician licenses, or that have restrictions on pharma-owned pharmacies).

As one McKinsey report suggested, communicating with regulators early can reduce uncertainty and accelerate approval pathways. The companies that do this well often earn regulators' trust as partners, which can even expedite feedback if post-launch tweaks are needed.

The Future of DTP Enablement

Recent trends indicate that DTP enablement is poised to become even more integral to the pharmaceutical industry, evolving alongside technological advances. 

This is where we believe DTP is likely headed in the coming years:

From Novelty to the New Normal

DTP is rapidly moving from an innovative pilot to an expected capability. Just as consumers now assume most retail brands offer online shopping and home delivery, patients will soon assume pharma brands offer direct access options. 

In five years, launching a new drug without some form of DTP channel could be seen as outdated. Industry surveys already indicate that half of pharma leaders expect DTP to be standard practice within 5 years

The competitive edge will shift from simply having DTP to how well you execute it compared to others. Companies that invest now in robust, scalable DTP infrastructure will be positioned as leaders, while late adopters may struggle to catch up on patient connectivity.

Deeper Integration with Healthcare Ecosystem

The next generation of DTP programs will integrate even more seamlessly with other healthcare services. 

Imagine a future where a patient’s journey might start on a pharma DTP portal and seamlessly connect to their electronic health record, their primary care doctor, or local lab services. For instance, if a patient needs a lab test to monitor therapy, the DTP platform could schedule an at-home lab draw or direct them to a partner lab, then automatically retrieve the results and share them with the prescribing doctor. 

Pharma companies might partner with health systems, payers, or digital health firms to integrate their DTP offerings into care management programs, enabling patients to move seamlessly between in-person care and manufacturer-provided digital services.

Advanced Data and Personalization

Given the increase in data and insights coming from DTP interactions, pharma will increasingly use technologies like AI and machine learning to derive insights and personalize patient support. 

For example, imagine predictive algorithms that identify which patients are at risk of non-adherence or dropping out, enabling proactive support (perhaps even before the patient realizes they need help).

On the operational side, AI can help optimize logistics by predicting when a patient will need a refill based on usage patterns and by improving route planning for deliveries to prevent delays. 

Frequently Asked Questions (FAQs)

What is Direct-to-Patient (DTP) enablement in pharma?

DTP enablement is a model where pharmaceutical companies coordinate the entire patient journey, from prescription to home delivery and ongoing support, through a digital, integrated system.

How is DTP different from direct-to-consumer (DTC) advertising?

DTC is promotional (ads, coupons, awareness campaigns), while DTP is operational (delivery, telehealth, payment, support). DTP ensures the patient receives, understands, and stays on therapy.

What types of medications work best for DTP programs?

Self-administered therapies, consumer-driven categories (e.g., dermatology, migraine, weight management), and specialty-lite products are ideal. These therapies don’t require frequent in-person monitoring and benefit from convenience-driven access.

Why are pharma companies investing heavily in DTP now?

Rising patient expectations, payer friction, and competitive pressure are driving adoption.

DTP improves access, increases adherence, and provides deeper visibility into the patient journey.

What are the biggest challenges in implementing DTP?

Regulatory complexity, fragmented technology, and internal organizational silos are the top barriers. Successful programs solve this through early compliance planning, integrated platforms, and cross-functional alignment.

Sources

  1. FiercePharma - "Direct-to-patient programs are in the works at 94% of pharmas…" https://www.fiercepharma.com/marketing/direct-patient-programs-are-works-94-pharmas-set-become-standard-practice-survey

  2. Insider Intelligence / eMarketer - "Consumers and doctors show support for direct-to-patient models in pharma" https://www.emarketer.com/content/consumers-doctors-show-support-direct-to-patient-models-pharma

  3. Rock Health - "Pharma’s direct-to-patient era: Building beyond table stakes" https://rockhealth.com/insights/pharmas-direct-to-patient-era-building-beyond-table-stakes/

  4. Drug Channels - "Guest Post: Direct-to-Patient 2.0" https://www.drugchannels.net/2025/10/direct-to-patient-20-why-todays-dtp.html

  5. ixlayer & DHC Group - "2025 Direct-to-Patient in Pharma Report" https://ixlayer.com/2025/10/14/pharmas-next-move-what-2025-survey-data-reveals-about-the-future-of-direct-to-patient-programs/

  6. Pharmaceutical Commerce - "Will Pharma’s Direct-to-Patient Push Disintermediate Wholesalers?" https://www.pharmaceuticalcommerce.com/view/pharma-direct-to-patient-disintermediate-wholesalers

  7. Congress - "Inflation Reduction Act of 2022" (H.R.5376) https://www.congress.gov/bill/117th-congress/house-bill/5376/text

  8. HHS/DEA - "Telemedicine Prescribing of Controlled Substances" https://www.hhs.gov/system/files/hhs-telemedicine-dea-final-508compliant.pdf

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Nicolas Kernick is Head of Growth and Operations at Develop Health, where he helps scale Al-driven solutions that streamline medication access and transform clinical workflows. He worked across the US and Europe for 10 years at BCG before leaving to join a tech startup called SandboxAQ. He holds a First Class Degree in Physics from the University of Cambridge and was a Baker Scholar at Harvard Business School. With a deep interest in healthcare innovation and technology, Nicolas writes about how Al can improve patient outcomes and reduce administrative burden across the heathcare ecosystem.

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